Kidney disease: What is it? When waste and fluid build up in the body, kidney disease results from the damaged kidneys. It differs and relies on factors including age, gender, size, and ethnicity. Initially, they may result in swelling in the legs, ankles, or feet, as well as tiredness, shortness of breath, frequent urination, blood in the urine, loss of appetite, weight loss, and other symptoms. CKD, or chronic kidney disease Overview It could be …