CREATININE

Creatinine

The nitrogenous waste product creatine is synthesized by the metabolism of creatine phosphate in skeletal muscle and protein metabolism. Creatine is excreted in the urine after being filtered from the blood by the kidneys. In this article, we will know about the creatine level, creatine serum, and creatinine level normal, and so on.

Creatinine Formed in our Body

  • Many organs, such as the liver, pancreas, and kidneys, generate creatine from amino acids such as arginine, glycine, and methionine.
  • Creatine is carried through the circulatory system to muscles, brains, and other organs, where it is metabolized to phosphocreatine and acts as energy storage comparable to ATP.
Creatinine Test (2)
  • When creatine and phosphocreatine are broken down the creatine metabolite is produced.
  • Although muscle produces the majority of creatine, the quantity of creatine detected in the blood is related to the patient’s lean mass.
  • The waste product, creatine, enters the blood supply, where it’s removed by the kidneys.

Normal Value of Creatinine

  • In adult males, the normal creatine level should be from 0.7 to 1.2 mg/dL,
  • In adult females, the normal creatine level should be from 0.4 to 1.0 mg/dL and,
  • For children in the age group of 3 to 18 years, the normal creatine level should be from 0.5 to 1.0 mg/dL
  • For children less than 3 years of age 0.3 to 0.7 mg/dL.

Creatinine Test

A creatine test determines the total concentration of the substance creatine in the blood or urine. There are two types of creatine tests: 

Creatinine Test
  • A serum creatine test measures the proportion of creatine in a blood sample, and a urine creatine test provides a measure of creatinine in a sample of urine.
  • A urine creatine test assesses the total volume of creatine in all of the urine generated over the course of 24 hours, and a creatine clearance test compares these two numbers.

Why is a creatinine test done?

The creatine test is ordered by a nephrologist in case of any of the following scenarios:

  • To diagnose kidney disease if any signs and symptoms are seen.
  • To monitor the ongoing treatment or to assess the progress.
  • To detect kidney dysfunction. if the patient has diabetes, high blood pressure, or other factors that make kidney disease more likely.
  • To look for adverse effects from medications that might cause kidney injury or impairment.
  • To determine the function of a transplanted kidney.

High Creatinine level Imply

An elevated level of creatine in our body can indicate that our kidneys are not functioning properly and are having possible kidney impairment. When the kidneys deteriorate for any reason, blood creatine levels rise due to poor creatine clearance by the kidneys. This test can be a biomarker of health conditions like chronic kidney disease.

Cause for a High Creatinine level

  • The creatine level in our body can rise due to various reasons such as :
  • Increased dietary intake of meat 
Creatinine level
  • Large muscle mass
  • Disease conditions like nephrotic syndrome, diabetic nephropathy, Renal failure 
  • Excess of exercise
  • Taking certain medications such as antibiotics and NSAIDs (non-steroidal anti-inflammatory drugs ) like Naproxen sodium, Celecoxib, Oxaprozin 

High Creatinine level Show Symptoms

A spike in creatine levels may indicate that the kidneys are failing. The following are some of the signs and symptoms of renal disease:

  • Frequent tiredness
  • Swelling in feet or ankles
  • Poor appetite
  • Puffiness around eyes
Creatine symptoms
  • Dry, itchy skin
  • Muscle cramps
  • Frequent urination
  • Foamy urine
  • Painful urination
  • Blood or protein in the urine
  • Difficulty sleeping

Results of Creatinine level Show

There are several ways to interpret creatinine results in the blood or urine, including:

Serum Creatinine Level

Creatinine usually enters the circulation at a steady pace and exits at the same rate. Serum creatinine levels that are too high might suggest that the kidneys aren’t working properly.

Glomerular Filtration Rate (GFR)

Measurement of serum creatinine can also be used to estimate the efficiency of the kidneys in filtering blood. As serum creatinine varies from person to person, the GFR provides a more accurate assessment of kidney function.

Creatinine Clearance 

  • Creatinine clearance assesses how well the kidneys clear creatinine from the bloodstream so that it may be excreted in the urine.
  • Creatinine clearance is commonly determined over a 24-hour period by monitoring creatinine concentrations in urine and serum samples. Urine samples can also be obtained in a less time-consuming manner. The collection and timing of the urine sample are crucial.
  • Creatinine clearance (ml/min / BSA) is expressed in milliliters per minute per square meter of body surface area.
  • Creatinine clearance usually varies from 77 to 160 ml/min / BSA in males aged 19 to 75.
  • The range of creatinine clearance in women varies according to age:
  • 18 to 29 years old: 78 to 161 ml / min / BSA 
  • 30 to 39 years old: 72 to 154 ml / min / BSA 
  • 40 to 49 Years: 67 to 146 ml / min / BSA 
  • 50 to 59 years: 62 to 139 ml / min / BSA 
  •  60 to 72 years: 56 to 131 ml / min / BSA 

When the results are below the usual range, the kidneys may be under-performing or there may be conditions that affect blood flow.

Albumin/Creatinine Ratio 

An alternative interpretation for creatinine levels in urine is the albumin/creatinine ratio, a measurement that is based on a blood protein called albumin.

  • Usually, a healthy kidney does not filter albumin from the blood, so the urine shouldn’t contain any albumin.
  • The albumin/creatinine ratio reveals how much albumin is found in a urine sample compared to how much creatinine is present.
  • The results are reported as milligrams (mg) of albumin per gram (g) of creatinine.
  • The results that indicate a healthy kidney is: 
  • Less than 17 mg / g in adult men.
  • Less than 25 mg / g in adult women

Generally, high blood creatinine and low urine levels indicate kidney disease or other medical conditions that affect kidney function, including: 

  • Autoimmune disorders 
  • Bacterial kidney infection 
  • Urinary tract obstruction 
  • Heart failure 
  • Complications of diabetes

Maintain a Normal Creatinine Level

Cut down On Vigorous Exercise

  • A strenuous workout can additionally increase muscle work and spike creatine levels.
  • Thus, slight sorts of sporting events are recommended.
  • Consult your nephrologist to know how much and what kind of exercise you should do.

Herbal Or Green Tea

Chamomile tea, nettle leaf tea, and dandelion root tea can both act as diuretics in addition to assisting in removing creatine quickly through the urine.

Stay Hydrated

  • Excessive creatinine levels can also be caused by dehydration.
  • Make it a point to drink at least 6-8 glasses of water each day.

Reduce Protein Intake

  • Excessive protein-rich diets also can develop increased blood creatine levels.
  • Avoid ingesting cooked meat and change to a plant-primarily based food regimen.
Creatine healthy diet

Limit Sodium Intake

  • Diet excessive in sodium can also additionally cause excessive blood pressure and fluid retention that could cause excessive creatine levels.
  • Thus, decrease the intake of salt and choose upon a low sodium food regimen for excessive creatine levels.

Sleep Well

The metabolic rate of the body slows down while we sleep, lowering the body’s creatine levels. Certain foods and herbs have been shown to decrease creatine levels. However, You should consult your nephrologist/healthcare provider to know more about the following herbs and foods before using:

  • Chitosan supplements
  • Dandelion Root
  • Siberian Ginseng
  • Cinnamon
  • Sage
  • Astragalus

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