- Calcium salt
- Phosphate Binder
Control of Serum phosphorus: Chronic Kidney Disease:
Oral: Initially, 1334 mg with each meal is administered. This can be moderately increased (every 2 to 3 weeks) to bring the serum phosphate to the chosen range as long as hypercalcemia does not emerge. Here the usual dosage recommended is 2001 to 2668 mg calcium acetate along with each meal. No additional calcium acetate supplements are to be administered.
Dietary supplement (OTC): 1 to 3 tablets are to be consumed with meal thrice a day
Dosing: Renal Impairment: Adult:
No adjustment of dose is required
Dosing: Hepatic Impairment: Adult:
No adjustment of dose is provided in the manufacturer’s labelling.
Oral: The dose is to be taken along with the meals
The following adverse drug responses and appearances are derived from the product labelling unless otherwise mentioned:
Endocrine & metabolic: Hypercalcemia
Gastrointestinal : Diarrhea (oral solution)
Warnings and Precautions
Concerns about unfavorable effects:
- Gastrointestinal effects
Oral dosage forms must be consumed with meals to be fruitful
Mechanism of Action
It blends with dietary phosphate to form insoluble calcium phosphate, which is discharged in stools.
Pharmacodynamics and Pharmacokinetics
- Absorption: 30% to 40%
- Requires Vitamin D otherwise persistent high doses of calcium acetate are given
- Calcium is absorbed in the solution, Ionized form
- In an acid environment, solubility of the calcium is increased